The fourth part of our training series for frontline healthcare workers focuses on the compassionate medical care of perinatal persons with substance use disorders. Our subject matter expert addresses the unique challenges and health implications these individuals face and brings a heightened understanding to some of the psychological and physiological barriers of these disorders. We offer valuable insights, evidence-based strategies and demonstrate how healthcare professionals can play a pivotal role in fostering healthy outcomes for the substance exposed dyad, through informed and empathetic care.